So, assuming you aren't surprised, a consequence of this is that the Missile phase of the first round of combat often has players readying their weapons. This isn't a real problem for people using melee weapons because they will get to ready their weapon (and move) then attack in the upcoming melee phase. However folks using ranged weapons are a bit S.O.L in this situation. If you ready your crossbow you will miss firing it in the missile phase and have to wait out the melee phase. Well you can move both phases (up to 120 feet/yards if you move in both phases) anyway to get out of the fray and line up a shot. I don't have a problem with this either I'm certain dedicated bowmen will deal with this as part of their tactics - but I'm pretty sure it will discourage the more casual use of things like throwing daggers, darts and hand axes.
There are two ways to handle this that I can see.
|one way to handle it|
The second, and I believe better, way to do this is to make some weapons available instantly. No need to ready that dagger - just throw it. This appeals to my sense of narrative because - hey there's a dagger in your throat - and it would give a good reason for characters to carry certain weapons for these situations. It also fits with the idea of unarmed combat - there is no way to justify making players miss a round of melee because they didn't ready their fists. Making the cestus (your basic steel belted or spiked mittens) available for attack without being readied* only makes sense, why not just extend this to daggers, darts, staves and spears** as well.
* when you are wearing them, and you better not try wearing them 24/7 and eating your dinner or hanging out at the bar with them on however.
**well if you are carrying them like a walking stick maybe?